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KMID : 0376219700070020129
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Chonnam Medical Journal
1970 Volume.7 No. 2 p.129 ~ p.138
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Influence of chlorpropamide on the renal function of the dog
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Abstract
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In view of clinical observations that chlorpropamide, an oral hypoglycemic, has a favorable effect also in cases of diabetes insipides, the renal action of the sulfonylurea was investigated in this study.
Chlorpropamide, when given intravenously in doses ranging from 1 to 13㎎/㎏, elicited antidiuresis either during water diuresis or during mannitol diuresis, the response increasing roughly in proportion to the dose. Also, the renal plasma flow(C_(pAH) and glomerular filtration rate(C..) decreased in proportion, The decrements in osmolar clearance, uriuary excretion of sodium and free water clearance, as well as the decrease in urine flow correlated significantly with the decrease in the filtration, indicationg that the antidiuresis is effected mainly by the decrease in glomerular filtration rate by chlorpropamide, though direct action on the tubular function cannot be ruled out.
In experiments, in which the agent was infused directly into a renal artery and urines from both ureters collected separately, a small dose of 0.01㎎/㎏/min produced antidiuresis confined only to the infused side and without concomitant changes in glomerular filtration rate, inferring that the renal action of chlorpropamide is not mediated by any endogenous humoral agent, and that it has an action, though weak and masked ordinarily by the hemodynamic action, direct on the permeability of the tubules of distal portions.
During mannitol diuresis and under the influence of sufficient amount of vasopressin, chlorpropamide could not affect the reabsorption of solute-free water(T^(6)H_(3)O) suggesting that Henle´s loop and vasa recta are not influenced by it.
It is thus concluded that chlorpropamide induces antidiuresis, mainly by decreasing glomerular filtration rate, and partly by decreasing the tubular permeabilty to water in the dog.
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KEYWORD
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